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Reason #1: I am tested, qualified and approved from birth to reign

Reason #1: I am tested, qualified and approved from birth to reign

21 Reasons Why I Am BORN TO REIGN

Further elimination and reselection sets in at the cervix!

 

Sperm enter the cervical canal rapidly where they encounter cervical mucus. Under the influence of oestrogen during ovulation the cervix secretes highly hydrated mucus, often exceeding 96% water in women (Katz et al, 1997).  Cervical mucus presents more of a barrier to sperm of abnormal morphology and poor motility and is considered to be a means of sperm selection, supporting the passage of normal motile sperm while discouraging passage of microbes and sperm with abnormal motility (Hanson and Overstreet, 1981; Barros et al, 1984; Katz et al, 1990; 1997).




Cervical mucus has also been shown in vitro to be a selective barrier against spermatozoa that though morphologically normal are carrying genetic structural abnormalities (Bianchi et al, 2004). The greatest barrier to sperm penetration of cervical mucus is at its border, because here the mucus microarchitecture is more compact (Yudin et al, 1989).

 

Capacitation and hyperactivation for successful transit!

 

Sperm undergo two changes in preparation for fertilisation: capacitation and hyperactivation that together may serve to firstly detach spermatozoa from their isthmic ‘reservoir’ and then speed sperm movement to the ampulla as the time of ovulation approaches. So, those who make it this far are given a helping hand to prepare for the next phase. They undergo some sort of configuration or fortification that enables them to move from isthmus to ampulla for ovulation.

Hyperactivation for final lap!

 

In aqueous solution hyperactivated sperm swim vigorously in circular or erratic patterns but in vivo the physical environment encountered by sperm is quite different and evidence indicates that hyperactivation is required by sperm to progress towards the oocyte and penetrate its vestments. Hyperactivation enhances the ability of sperm to swim through viscoelastic substances such as mucus in the tubal lumen and the extracellular matrix of the cumulus oophorus (Jansen, 1980). Hyperactivated sperm penetrate artificial mucus such as viscoelastic solutions of long-chain polyacrylamide or methylcellulose, far more effectively than non-hyperactivated sperm (Suarez et al, 1991b; Suarez and Dai, 1992; Quill et al, 2003). Hyperactivation also endows sperm with greater flexibility for turning around in pockets of mucosa (Suarez et al, 1983; Suarez and Osman, 1987) and may thus assist sperm in navigating the increasingly complex tubal maze.



Deselection of unsuccessful candidates (abnormal sperm)!

 

There is also evidence of a process whereby morphologically abnormal spermatozoa or non-capacitated or non-acrosome-reacted sperm are deselected by the oocyte and its surrounding cumulus cells. In vivo interaction between the oocyte and the few remaining sperm is likely to involve spermatozoa that are morphologically normal due to the selecting nature of the female reproductive system. Nevertheless evidence from in vitro work shows that those sperm able to traverse the cumulus mass were more likely to have normal morphology, be capacitated and acrosome-reacted with a distinct motility pattern and better zona-binding capacity suggesting that sperm selection continues to the end (Hong et al, 2004).

The ‘kamikaze’ lane!

 

The most notorious theory of sperm heterogeneity is the ‘kamikaze’ sperm hypothesis of Baker and Bellis (Baker and Bellis, 1998 and 1989) that proposed a functionally adaptive division of labour between sperm: ‘egg-getters’, ‘blockers’ and ‘killers’. Given that sperm consist of a diminutive single-cell structure, the ‘kamikaze’ theory holds that sperm carry a self-recognition system that must differentiate between genes. The egg-getter is what I call the born to reign sperm cell.

The killers are somehow designed by God, I believe, to get rid of any stray sperm cell on the track while the blockers are there to stop any other sperm cell from entering the dominion incubation chamber once the predestined one has made it through. So, we can say that at  the end of every fertilization process, we have some sort of retreat, over-comers, losers and perhaps escort sperm cells.

At the configuration chamber for dominion at last!

When the cell membranes of the sperm and oocyte merge, the sperm enters the ooplasm of the oocyte, triggering oocyte activation, a series of changes in metabolic activity including a rise in metabolic rate.

The cell membrane of the oocyte undergoes immediate electrical changes that block the entry of other sperm and enzymes produced by the fertilized ovum alter receptor sites so that sperm already bound are detached and others are prevented from binding.

Fertilization stimulates the ovum to complete its second meiotic division and form a diploid zygote, producing a large mature ovum. After oocyte activation and meiosis the nuclear material remaining within the ovum reorganises as the female pronucleus.

The successful spermatozoon enters the cytoplasm, its tail is shed and the nucleus in the head develops into a structure called the male pronucleus which in turn migrates to the centre of the cell and fuses with the female pronucleus. Within 12 hours genetic fusion has completed with the formation of a diploid zygote, a fertilised egg, which will in turn undergo cleavage and produce billions of specialised cells.




When I take a close look at all these, I come to the definite conclusion that I am not the product of an accident. I’m in this world to accomplish great things. I’m born to reign. I know who I am! I’m tested, qualified and approved from birth to reign on earth.

‘‘See, I have this day set thee over the nations and over the kingdoms, to root out, and to pull down, and to destroy, and to throw down, to build, and to plant.’’

Jeremiah 1:10

21 Reasons Why I Am BORN TO REIGN

Posted in Dominion, Faith, Supernatural